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KMID : 1012420160250010005
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Korean Journal of Obesity
2016 Volume.25 No. 1 p.5 ~ p.9
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Early Biomarkers Predicting Successful Weight Loss after Anti-obesity Intervention
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Lee Sang-Yeoup
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Abstract
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Weight loss of as little as 5-10% can result in improvement in cardiovascular and metabolic risks associated with obesity. Despite use of any weight loss intervention, whether pharmacological or non-pharmacological, approximately 50% of obese patients achieve a modest weight loss of 5% of initial body weight. Thus, it might be useful to predict weight-loss effectiveness at the beginning of treatment for establishment of an individually tailored strategy to effectively treat obesity. This review provides an overview of emerging biomarkers as pre-treatment predictors of weight loss or weight regain after intentional weight reduction in obese patients. Results suggests that leptin, aspartate transaminase, and circadian rhythm play roles as pre-treatment predictors of weight-loss effectiveness; retinol-binding protein 4, total testosterone, and sex hormone-binding globulin as predictors of weight regain; and fasting glucose as a predictor of successful long-term weight loss after Roux-en-Y gastric bypass.
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KEYWORD
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Obesity, Biomarker, Prediction, Treatment, Efficacy
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